New Cytotoxic and Antibacterial Compounds Isolated from the Sea Hare, Aplysia kurodai

Parguerol and Isoparguerol Isolated from the Sea Hare, Aplysia kurodai, Induce Neurite Outgrowth in PC-12 Cells

The extract of the sea hare, Aplysia kurodai, showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded two active compounds, which were subsequently identified to be parguerol and isoparguerol by spectroscopic analysis. It was found that both parguerol and isoparguerol induced neurite outgrowth in PC-12 cells at concentrations of 25 and 50 μM...

Synthetic Efforts for Stereo Structure Determination of Cytotoxic Marine Natural Product Pericosines as Metabolites of Periconia sp. from Sea Hare

Pericosines are unique C(7) cyclohexenoid metabolites of Periconia byssoides OUPS-N133 fungus that was originally isolated from the sea hare, Aplysia kurodai. Pericosines show significant in vitro cytotoxicity against P388 lymphocytic leukemia cells. Pericosine A, in particular, shows the most potent activity and significant in vivo antitumor activity against P388 cells. Thus, pericosines are p...

An Examination of the Antibacterial Effect of the Ink of Persian Gulf’s Sea Hare Aplysia dactylomela on Some Aquatic Pathogens

,Different variations of Aplysia have been appealing options in medical and pharmaceutical researches for years. Persian Gulf’s sea hare—Aplysia dactylomela—is a species native to Persian Gulf and can be evaluated in various areas. In this research, carried out in 2019 in Persian Gulf University’s Research Centre, the antibacterial potential of the ink of this species has been measured against ...

Aplysiasecosterols B and C: two new 9,11-secosteroids with a cis-fused 1,4-quinone structure from the sea hare Aplysia kurodai

Molecular Identification of the Persian Gulf Sea Hare (Aplysia sp.) Based on 16s rRNA Gene Sequence

Background: Sea hares of the Aplysia genus are among the mollusks of interest for various researchers to study their phylogeny, bioactive compounds and the nervous system. These mollusks are herbivorous and produce chemical compounds (ink) to defend themselves. The present study provided molecular identification of the Persian Gulf (Bushehr city) sea hare using 16s rRNA gene sequence. Materials...